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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: J Cardiovasc Electrophysiol. 2011 Oct 28;23(4):423–432. doi: 10.1111/j.1540-8167.2011.02196.x

Figure 1.

Figure 1

Effect of amitriptyline on the electrophysiology of the coronary-perfused right ventricular wedge preparation in the absence and presence of the transient outward current agonist NS5806. The top panels show transmembrane action potentials simultaneously recorded from 2 epicardial (Epi) and one endocardial (Endo) site together with a pseudo-electrocardiogram (ECG). (A) Control and amitriptyline (0.2 μM). (B) Control followed by NS5806 (8 μM) and NS5806+amitriptyline (0.2 μM). Basic cycle length (BCL) = 2,000 ms; n = 4. (C) Bar graph showing the effect of amitriptyline alone or in combination with NS5086 on notch magnitude, Phase 0-phase 2 interval and notch index. BCL = 2,000 ms; n = 9. Values are mean ± SD. †P < 0.01 vs control; ‡P < 0.001 vs control; ‡‡P < 0.001 vs NS5806.