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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: J Cardiovasc Electrophysiol. 2011 Oct 28;23(4):423–432. doi: 10.1111/j.1540-8167.2011.02196.x

Figure 3.

Figure 3

Effect of isoproterenol (100 nM) and quinidine (10 mM) to antagonize amitriptyline (0.2 μM)-induced accentuation of the action potential notch and J wave in the presence of the transient outward potassium channel current agonist NS5806. (A) Each panel shows transmembrane action potentials simultaneously recorded from one endocardial (Endo) and 2 epicardial (Epi) sites. Basic cycle length (BCL) = 2,000 ms. (B–D) Notch magnitude, Phase0-phase2 (Ph0–Ph2) interval and notch index are all significantly reduced following addition of isoproterenol (ISO) or quinidine to the coronary perfusate. BCL = 2,000 ms; n = 4. Values are mean ± SD. *P < 0.05 vs amitriptyline; †P < 0.01 vs amitriptyline; ‡P < 0.001 vs amitriptyline; **P < 0.05 vs isoproterenol; ‡‡P < 0.001 vs isoproterenol.