Table 2.
Genotype and allele frequency of the -2922(C)2-3 allele in Mexican American alcoholics and non-alcoholics controlling for confounding effect of smokers and obesity n (%)
| Groups |
Genotype |
Allele frequency |
||
| (C)2/(C)2 | (C)2/(C)3 | (C)3/(C)3 | (C)3 | |
| Non-alcoholic | ||||
| BMI < 30 kg/m2 (213) | 73 (34.3) | 78 (36.6) | 62 (29.1) | 202 (47.4) |
| BMI ≥ 30 kg/m2 (122) | 41 (33.6) | 48 (39.3) | 33 (27.0) | 114 (46.7) |
| Alcoholic | ||||
| BMI < 30 kg/m2 (198) | 37 (18.7) | 107 (54.0) | 54 (27.3)a | 215 (54.3)b |
| BMI ≥ 30 kg/m2 (146) | 37 (21.5) | 74 (50.7) | 35 (25.9) | 144 (49.3) |
| Non-alcoholic | ||||
| Non-smokers (282) | 100 (35.5) | 101 (35.8) | 81 (28.7) | 263 (46.6) |
| Smokers (59) | 17 (28.8) | 29 (49.2) | 13 (22.0) | 55 (46.6) |
| Alcoholic | ||||
| Non-smokers (197) | 49 (24.9) | 88 (44.7) | 60 (30.5)c | 208 (52.8) |
| Smokers (177) | 38 (21.5) | 104 (58.8) | 35 (19.8)d | 174 (49.2) |
a
P = 0.000 vs nonalcoholic body mass index (BMI) < 30 kg/m2;
b
P = 0.049 vs nonalcoholic BMI < 30 kg/m2;
c
P = 0.037 vs non-alcoholic non-smokers;
d
P = 0.016 vs alcoholic non-smokers.