Skip to main content
. 2012 Sep;10(3):231–238. doi: 10.2174/157015912803217314

Table 3.

Antidepressant-Like Effects of δ Opioid Receptor Agonists in Animal Models

# Author Year Compound Strain Dose Rote Test (Model)
1 Nagase et al. 2002 TAN-67 SD 1-10 mg/kg s.c. FSS
2 Broom et al. 2002 SNC80 SD 10-100 mg/kg s.c. FSS
3 Broom et al. 2002 (+) BW373U86 SD 1-10 mg/kg s.c. FSS
4 Saitoh et al. 2004 SNC80 ICR 0.3-3 mg/kg s.c. FSS/CSM
5 Torregrossa et al. 2005 (+) BW373U86 SD 10 mg/kg X 1, 8, 21 days s.c. FSS
6 Naidu et al. 2007 (-) NIH11082 C57BL6 8-32 mg/kg i.p. TST
7 Saitoh et al. 2008 SNC80 Wistar 1-10 mg/kg X 7 days s.c. HE OB rat model
8 Vergra et al. 2008 UFP-512 Swiss 0.001-0.1 nmol/0.01-1 mg/kg i.c.v./i.p. FSS
9 UFP-512 SD 0.1-1 mg/kg i.p. FSS
10 Le Bourdonnec et al. 2008 ADL5859 - 0.3-3 mg/kg p.o. FSS
11 Saitoh et al. 2011 KNT-127 ICR 0.1-1 mg/kg s.c. FSS
12 Hudzik et al. 2011 AZD2327 SD 1-10 mg/kg X 4 days p.o. LH

Abbreviation; FSS: Forced swim test, CSM: Conditioned suppressive motility, HE: Hyperemotionality score, LH: Learned helplessness test