Fig. (2).

Different layers of molecular interactions in a biological system. A) Life as a system is composed of information from different layers, modified based on [6]. B) Different approaches for mapping interactions within and between different layers. 3C (Chromosome Conformation Capture), Hi-C (High-throughput Chromosome Capture), FISH (Fluorescence In Situ Hybridization), AGO-IP (Argonaute Immunoprecipitation), BiFC (Bimolecular Fluorescence Complementation), Y2H (Yeast Two-Hybrid), TAP (Tandem Affinity Purification), Co-IP (Co- Immunoprecipitation), EMSA (Electrophoretic Mobility Shift Assay), Y1H (Yeast One-Hybrid), ChIP (Chromatin Immunoprecipitation), RIP (RNA Immunoprecipitation), CLIP (Cross Linking and Immunoprecipitation).