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(A) Schematic representation of binding of the proposed polyvalent inhibitors to gp120 in the envelope glycoprotein spikes that are exposed on the surface of the HIV-1 virion. The dimensions of the spike proteins are described in Ref 38 and the dimensions of HIV-1 as well as the spacing of spikes is derived from Ref 6. (B) Schematic outline of the synthesis of the proposed side chain CDR H3 peptide-synthetic polymer inhibitors.
