Table 1. Activity of 2-Substituted Macrocycles in Shh-Induced C3H10T1/2 Cell Differentiation.


Relative to cyclopamine (100%).
Measured by alkaline phosphatase activity.
Measured by Gli1 levels. See the Supporting Information for details.


Relative to cyclopamine (100%).
Measured by alkaline phosphatase activity.
Measured by Gli1 levels. See the Supporting Information for details.