Figure 2.

Demonstration that the binding of the TCR to agonist peptides induces dimerization of TCRs, leading to two TCRs binding stably to one peptide: MHC class I molecule, whereas antagonist peptides that induce positive selection lead to binding but not TCR dimerization. The results with agonist peptide can be seen only at 37°C and not at 25°C. Data from Alam et al. (29).