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Effects of subcutaneously administered hesperidin and hesperidin-3′-O-methylether (a) and Ro 20-1724 (b) on the duration of xylazine (10 mg/kg, i.p.)/ketamine (70 mg/kg, i.p.)-induced anesthesia in mice. Ro 20-1724 was administered 0.25 h and hesperidin and hesperidin-3′-O-methylether 1 h before anesthesia. *P < 0.05, ***P < 0.001, compared to the vehicle (control). Each value represents the mean ± SEM. The number of mice in each group was 10.
