Figure 4.

Blood pressure (mmHg) was measured with the use of Millar catheter cannulation of the right carotid artery of transgenic mice at age 10–12 weeks. Systolic blood pressure is shown as the open bar, diastolic blood pressure as the solid bar, and mean arterial pressure as the striped bar. Elevation in all three values was observed in the tTA+/RVCH+ group relative to the control littermates. In the subgroup of tTA+/RVCH+ mice given doxycycline (Dox) in the drinking water at 200 μg/ml from 6–12 weeks of age, values were indistinguishable from those for control littermates ± Dox. Values are depicted as means ± SEM of 8–20 independent experiments. *, P < 0.05 vs. all other groups.