Figure 1.

Effect of UP446 in carrageenan-induced paw edema: Male Wistar rats (N = 12) were given intraplantar injection of carrageenan λ (100 μl of 1% [w/v] in saline) into the plantar surface of right hind paw of sedated rats at time 0 (T = 0). Rats were treated orally with UP446 (150 mg/kg) or ibuprofen (150 mg/kg) 30 min before carrageenan inoculation. Paw edema was measured with the use of Plethysmometer at time 0 (before carrageenan), 1 hr, 2 hr, 4 hr, and 6 hr after carrageenan. Paw edema change was determined by subtracting 1 hr, 2 hr, 4 hr, and 6 hr individual values from their respective T0 value. Data are expressed as mean ± SD. ^*P ≤ .05 vs. vehicle.