Table III.
Studies on amlodipine and nifedipine gastrointestinal therapeutic system (GITS) reporting muscle sympathetic nerve activity.
| Referencea | Year | n | Mean age (years) | Dose (mg) | Time interval (weeks) | %Δ in SBP | %Δ in DBP | %Δ in HR | %Δ in MSA |
|---|---|---|---|---|---|---|---|---|---|
| Amlodipine | |||||||||
| Calhoun (52) | 1997 | 10 | 47 | 10 | 4 | –9.6 | –7.6 | 2.9 | 40.0 |
| Binggeli et al. (32) | 2002 | 14 | 58 | 5 | 8 | –9.7 | –9.6 | –4.6 | 6.1 |
| Struck et al. (30) | 2002 | 18 | 56 | 5 | 1 | –9.1 | 32.1 | ||
| Ruzicka et al. (37) | 2007 | 10 | 42 | 5 | 6 | –4.6 | –4.4 | –2.7 | –3.9 |
| Dodt et al. (53) | 2000 | 18 | 56 | 5 | 1 | –9.1 | –5.3 | 6.0 | 32.6 |
| Total | 70 | ||||||||
| Mean | 51.8 | ||||||||
| Mean % change | –8.4 | –6.7 | 0.4 | 21.4 | |||||
| SE | 0.97 | 1.04 | 2.19 | 8.54 | |||||
| Nifedipine GITS | |||||||||
| Ruzicka et al. (49) | 2004 | 10 | 45 | 20 | 4 | –0.76 | –1.012 | 2.94 | 4.88 |
| Ruzicka et al. (49) | 2004 | 8 | 67 | 20 | 4 | –6.85 | –8.05 | 3.08 | 8.51 |
| Total | 18 | ||||||||
| Mean | 56 | ||||||||
| Mean % change | –3.81 | –4.53 | 3.01 | 6.69 | |||||
| SE | 3.04 | 3.52 | 0.07 | 1.82 | |||||
SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; MSA, muscle sympathetic nerve activity; %Δ, percentage change.
a
Each reference is an independent study published reporting on the relevant parameters indicated with % changes calculated on the group means.