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. 2012 Oct 3;2012:782970. doi: 10.1155/2012/782970

Figure 6.

Figure 6

IGF1 increases de novo Cer formation. Levels of (a) C16 : 0-Cer and (b) C18 : 0-, C22 : 0-, C24 : 0-, and C24 : 1-Cer in VH-64 cells incubated for the indicated times with IGF1 (100 ng/mL). (c) Levels of sphinganine (SA) and sphingosine (SO) in VH-64 cells treated for 72 hours with IGF1 (100 ng/mL) in the absence and presence of FB1 (30 μM). (d) Percentage of different Cer species in VH-64 cells treated for 72 hours with IGF1 (100 ng/mL) in the absence (white columns) and presence (grey columns) of FB1 (30 μM). Values of vehicle-treated controls for the different Cer species were set to 100%. Error bars: mean ± SD of triplicate determinations.