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. 2012 Oct 3;2012:782970. doi: 10.1155/2012/782970

Figure 7.

Figure 7

Functional consequences of Cer formation. (a) Percentage of viable VH-64 cells treated for 72 hours without (°, ●) and with (□, ■) IGF1 (100 ng/mL) in the absence (open symbols) and presence (closed symbols) of FB1 (30 μM), followed by incubation for 18 hours with the indicated concentrations of Apo2L/TRAIL. (b) EIA analysis of XIAP in VH-64 cells treated for 72 hours without and with IGF1 (100 ng/mL), in the presence of the indicated concentrations of FB1. (c) Ratio of phosphorylated AKT to total AKT determined by ELISA in VH-64 cells treated for 72 hours without and with IGF1 (100 ng/mL) in presence of the indicated concentrations of FB1. Asterisks: *P < 0.05, **P < 0.02; error bars: mean ± SD of quadruplicate determinations from 3 independent experiments.