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. 2012 Feb 17;127(1):10–17. doi: 10.1093/toxsci/kfs088

TABLE 3.

Severity Ranking of Effects and Benefits and Multipliers to the Frameworka

Multiplier to the incidence of effect/benefit
EPA severity ranking of effects
    NOEL (no effect) 0
    NOAEL (nonadverse effect) 1
    (LO)AEL (adverse effect) 2
    FEL (frank toxicity) 3
“Severity” ranking of benefits
    None 0
    Minimal (decreased arthritis) 1
    Moderate (lower blood pressure) 2
    Maximum (decreased CHD) 3

Note. CHD, coronary heart disease; FEL, frank effect level; LOAEL, lowest observed adverse effect level; NOAEL, no observed adverse effect level; NOEL, no observed effect level.

a

Please note the intended association of the term “severity” with “benefits.” In order to balance risks with benefits, matching schemes, and terminology, seem appropriate.