Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
An integrated model of AMD pathogenesis. Aging is the primary driver of early cellular defects in photoreceptors and retinal pigment epithelium (RPE); these changes are exacerbated (or inhibited) by specific genetics variants. Complement and immune response pathways play critical roles in the onset and severity of disease.
