Table 2.
Comparison of KIR gene frequencies for subjects with autism from the UT/OR and AGRE populations against the CEPH control population. The two autistic populations were compared separately and then combined when compared to the control population.
CEPH Controls |
UT/OR(n=70) | AGRE(n=88) | Combined UT/OR & AGRE(n=158) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
KIR | UT/OR | OR | 95% CI | p-value | AGRE | OR | 95% CI | p-value | Both | OR | 95% CI | p-value | |
2DS2 | 97 | 37 | 0.89 | (0.51, 1.56) | 0.682 | 53 | 1.20 | (0.71, 2.03) | 0.489 | 90 | 1.05 | (0.68, 1.62) | 0.824 |
2DS3 | 46 | 24 | 1.47 | (0.81, 2.69) | 0.203 | 30 | 1.46 | (0.84, 2.55) | 0.180 | 54 | 1.47 | (0.92, 2.35) | 0.110 |
2DS5 | 53 | 33 | 2.04 | (1.15, 3.61) | 0.014 | 35 | 1.51 | (0.88, 2.58) | 0.133 | 68 | 1.72 | (1.10, 2.71) | 0.018 |
3DS1 | 65 | 41 | 2.41 | (1.37, 4.26) | 0.002 | 42 | 1.56 | (0.93, 2.62) | 0.093 | 83 | 1.89 | (1.22, 2.93) | 0.004 |
2DS1 | 67 | 45 | 2.93 | (1.64, 5.22) |
0.0003 0.025* |
50 | 2.14 | (1.27, 3.61) | 0.004 | 95 | 2.45 | (1.58, 3.82) |
0.00007 0.006* |
2DS4 | 160 | 68 | 3.40 | (0.76, 15.3) | 0.109 | 86 | 8.60 | (1.11, 66.6) | 0.038 | 154 | 5.13 | (1.45, 18.1) | 0.010 |
2DL2 | 96 | 38 | 1.06 | (0.60, 1.86) | 0.851 | 50 | 1.10 | (0.65, 1.84) | 0.726 | 88 | 1.08 | (0.70, 1.67) | 0.733 |
2DL3 | 162 | 66 | 1.90 | (0.53, 6.88) | 0.325 | 78 | 0.67 | (0.29, 1.59) | 0.366 | 144 | 0.96 | (0.43, 2.11) | 0.913 |
2DL1 | 172 | 68 | 0.79 | (0.14, 4.46) | 0.789 | 85 | 0.66 | (0.14, 3.03) | 0.590 | 153 | 0.71 | (0.19, 2.71) | 0.617 |
3DL1 | 174 | 64 | 0.12 | (0.02, 0.63) | 0.011 | 84 | 0.24 | (0.04, 1.36) | 0.105 | 148 | 0.17 | (0.04, 0.79) | 0.024 |
2DL5A | 63 | 39 | 2.16 | (1.22, 3.80) | 0.008 | 41 | 1.50 | (0.89, 2.53) | 0.130 | 80 | 1.75 | (1.30, 2.74) | 0.012 |
Bold type p-values significant at the p≤0.05 level. Bonferroni allelic corrected p-values significant at the p≤0.05 are listed below in Bold type*.