Early signs
|
More water intake
|
Greater decreases in numbers of total WBCs
|
More γ-H2AX formation in Lin+ bone-marrow cells
|
Similar decreases in survivin protein
|
Increased serum concentrations of IL-1β, -6, -8, G-CSF, and Flt-3 ligand
|
Intermediate signs
|
Faster body-weight decreases
|
Slower wound-healing rate
|
Greater decreases in numbers of RBCs and platelets
|
Less γ-H2AX formation in PBMCs
|
Greater increases in serum concentrations of IL-1β, -6, -8, and G-CSF
|
Late signs
|
Sustained elevated serum concentrations of IL-8 and G-CSF
|
|
More mortality
|
|
Slower wound-healing rate |