Table 3. LINE-1 DNA Methylation according to micronutrient status in 568 school-age children from Bogotá, Colombia.
| |
LINE-1 DNA Methylation (%5mC)2 |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| |
N1 | All |
N1 | Males |
N1 | Females |
|||
| Mean (SD) | %5mC difference (95% CI) | Mean (SD) | %5mC difference (95% CI) | Mean (SD) | %5mC difference (95% CI) | ||||
| Erythrocyte Folate, nmol/L |
|
|
|
|
|
|
|
|
|
| Q1 |
139 |
80.24 (0.61) |
Reference |
64 |
80.32 (0.60) |
Reference |
75 |
80.13 (0.59) |
Reference |
| Q2 |
139 |
80.21 (0.64) |
-0.03 (-0.18, 0.11) |
64 |
80.31 (0.65) |
-0.01 (-0.23, 0.20) |
74 |
80.17 (0.66) |
0.04 (-0.16, 0.24) |
| Q3 |
139 |
80.25 (0.67) |
0.01 (-0.14, 0.16) |
65 |
80.41 (0.62) |
0.09 (-0.11, 0.30) |
75 |
80.11 (0.69) |
-0.02 (-0.23, 0.18) |
| Q4 |
139 |
80.28 (0.67) |
0.04 (-0.11, 0.19) |
64 |
80.46 (0.68) |
0.14 (-0.09, 0.36) |
75 |
80.14 (0.63) |
0.01 (-0.19, 0.20) |
| P trend3 |
|
0.51 |
|
|
0.15 |
|
|
0.90 |
|
| Plasma Vitamin B12, pmol/L |
|
|
|
|
|
|
|
|
|
| Q1 |
137 |
80.30 (0.64) |
Reference |
64 |
80.40 (0.69) |
Reference |
72 |
80.19 (0.58) |
Reference |
| Q2 |
136 |
80.26 (0.61) |
-0.04 (-0.19, 0.11) |
63 |
80.41 (0.63) |
0.01 (-0.22, 0.24) |
72 |
80.13 (0.53) |
-0.06 (-0.24, 0.12) |
| Q3 |
134 |
80.24 (0.66) |
-0.06 (-0.22, 0.09) |
64 |
80.38 (0.63) |
-0.02 (-0.25, 0.21) |
72 |
80.12 (0.69) |
-0.07 (-0.28, 0.14) |
| Q4 |
136 |
80.18 (0.72) |
-0.12 (-0.28, 0.04) |
64 |
80.26 (0.64) |
-0.15 (-0.38, 0.08) |
72 |
80.11 (0.78) |
-0.07 (-0.30, 0.15) |
| P trend3 |
|
0.15 |
|
|
0.20 |
|
|
0.52 |
|
| Serum Zinc, μmol/L |
|
|
|
|
|
|
|
|
|
| Q1 |
140 |
80.22 (0.66) |
Reference |
66 |
80.33 (0.65) |
Reference |
75 |
80.13 (0.64) |
Reference |
| Q2 |
142 |
80.23 (0.64) |
0.01 (-0.14, 0.16) |
65 |
80.36 (0.65) |
0.03 (-0.19, 0.25) |
76 |
80.12 (0.63) |
-0.01 (-0.22, 0.19) |
| Q3 |
141 |
80.30 (0.64) |
0.07 (-0.08, 0.23) |
65 |
80.43 (0.62) |
0.10 (-0.11, 0.32) |
75 |
80.16 (0.62) |
0.03 (-0.17, 0.23) |
| Q4 |
141 |
80.24 (0.68) |
0.02 (-0.14, 0.18) |
66 |
80.36 (0.67) |
0.04 (-0.19, 0.26) |
76 |
80.15 (0.69) |
0.01 (-0.20, 0.22) |
| P trend3 |
|
0.60 |
|
|
0.61 |
|
|
0.82 |
|
| Plasma ferritin, μg/L |
|
|
|
|
|
|
|
|
|
| Q1 |
141 |
80.34 (0.66) |
Reference |
66 |
80.49 (0.65) |
Reference |
75 |
80.17 (0.62) |
Reference |
| Q2 |
139 |
80.18 (0.63) |
-0.16 (-0.31, -0.01) |
66 |
80.35 (0.63) |
-0.14 (-0.35, 0.08) |
76 |
80.10 (0.65) |
-0.07 (-0.27, 0.14) |
| Q3 |
143 |
80.26 (0.64) |
-0.08 (-0.24, 0.07) |
64 |
80.31 (0.61) |
-0.17 (-0.39, 0.04) |
75 |
80.15 (0.63) |
-0.01 (-0.21, 0.19) |
| Q4 |
141 |
80.21 (0.68) |
-0.13 (-0.28, 0.03) |
66 |
80.33 (0.69) |
-0.16 (-0.38, 0.07) |
76 |
80.14 (0.69) |
-0.02 (-0.23, 0.19) |
| P trend4 |
|
0.22 |
|
|
0.16 |
|
|
0.96 |
|
| Plasma vitamin A, μmol/L |
|
|
|
|
|
|
|
|
|
| < 0.700 |
72 |
80.37 (0.63) |
Reference |
34 |
80.40 (0.59) |
Reference |
38 |
80.35 (0.67) |
Reference |
| 0.700 - 1.049 |
235 |
80.32 (0.63) |
-0.06 (-0.22, 0.11) |
111 |
80.45 (0.67) |
0.05 (-0.18, 0.29) |
124 |
80.20 (0.57) |
-0.16 (-0.39, 0.07) |
| ≥ 1.050 |
260 |
80.16 (0.67) |
-0.22 (-0.38, -0.05) |
118 |
80.29 (0.63) |
-0.10 (-0.33, 0.12) |
142 |
80.04 (0.69) |
-0.31 (-0.55, -0.07) |
| P trend3 | 0.002 | 0.13 | 0.006 | ||||||
1Totals may be < 568 for all children, < 263 for males, and < 305 for females because of missing values. 2From mixed effects linear regression models where site was a random effect. 3From univariate regression models in which a variable representing the ordinal predictor was introduced as continuous.