Figure 1. Optimal selection of number of reads quality cut-off in RRBS data. (A) Frequency distribution of number of reads in RRBS data. X-axis is truncated at 200 reads but maximum in data are 45,972. (B) Correlation between Infinium 450K and RRBS values using different read cutoffs for RRBS data, estimated using Pearson R (black squares) and Spearman R (black circles) values. Number of CpGs shared between the two technologies and remaining after read cut-offs are indicated by red stars.