Figure 6. Effects of previous sepsis on clock gene product expression in the SCN.

Expression patterns of PER1 (A), PER2 (B), CLOCK (C) and c-FOS (D) were examined in the SCN of animals treated one month previous with either saline or LPS and then sampled every 4 hours across the 24 hour cycle in DD. n = 4–5 per timepoint per group. Note the significant change of expression of PER2 in the SCN of LPS treated animals.