Table 1. Effects on metabolic parameters in plasma.

Parameter	Control	Calorie restriction	β lapachone
GOT	149±11.8	156.9±17.1	173.7±26.7
GPT	46.1±4.0	64.2±3.9*	53.6±6.5
Cholesterol	121.7±11.4	87.5±7.0*	93.0±4.5*
Triglycerides	101.6±32.6	30.4±4.8*	84.5±16.7#
HDL	64.7±6.3	55.1±4.3	55.7±2.5
LDL	8.1±0.8	6.1±0.7	7.9±0.7
LDH	807.9±59.5	767.4±43.3	1013.0±109.2
Creatinine	0.2±0.02	0.2±0.01	0.2±0.01
IP	7.6±0.8	7.0±0.6	7.8±0.4
BUN	28.1±1.4	26.7±1.6	28.0±0.8
Glucose	214.0±39.9	184.0±9.6	166.0±9.6
Insulin	565.7±242.3	435.6±82.8	285.7±47.3
Leptin	9.6±3.5	8.6±1.3	2.9±0.6* #
Resistin	1.5±0.1	1.0±0.1*	1.3±0.1#

Data are the mean±s.e.m. (n = 5–10 per group).

^*p<0.05 versus control;

^#p<0.05 versus Calorie restriction.