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. 2012 Oct 11;7(10):e47219. doi: 10.1371/journal.pone.0047219

Figure 5. The antitumor effect of HCA587 protein vaccine is mediated by CD4+ T lymphocytes.

Figure 5

Tumor inoculation and vaccination was performed as described above except that some groups of the mice (10–15 for each group) received additional injections of 500 µg of GK1.5 (rat anti-mouse CD4 mAb), 53-6.7 (rat anti-mouse CD8 mAb), or isotype controls 1 day before the vaccination and twice a week thereafter for a total of eight times. The group of mice (n = 7) received tumor cells but no vaccination served as controls. (A) Tumor size. Points, mean of tumor volume; bars, SE. *, P<0.05; ns, P > 0.05, compared with untreated control group. (B) Survival curve of the mice. **, P<0.01; *, P<0.05, compared with untreated control group.