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. 2012 Oct 15;23(20):3970–3981. doi: 10.1091/mbc.E12-05-0352

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© 2012 Holt et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — Earlier loss of MAD2 from kinetochores during prometaphase in Fzr1^−/− oocytes. (A) Representative confocal z-stack images of MAD2/CREST immunostained in fl/fl and Fzr1^−/− oocytes fixed during prometaphase. Arrowheads and insets indicate sites of intense MAD2 accumulation at predicted spindle poles for Fzr1^−/− oocytes, similar to fl/fl oocytes at 4.5 h post GVB. (B) Kinetochore MAD2/CREST intensity ratios from at 1.5 and 2.5 h post GVB (p < 0.001; Kruskal–Wallis test with Dunn's post hoc test). Error bars (B) show SD; parentheses show numbers of kinetochores analyzed. Scale bar in A, 10 μm.