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. 2012 Oct 15;23(20):3970–3981. doi: 10.1091/mbc.E12-05-0352

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© 2012 Holt et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 9: — Increased rates of homologue nondisjunction in Fzr1^−/− oocytes. (A) Representative confocal image of a monastrol-induced spread from a meiosis II (MII) egg used for aneuploidy analysis. (B) Aneuploidy rates in fl/fl and Fzr1^−/− oocytes matured in vitro. *p = 0.045; χ². (C) Kinetochore counts from individual eggs scored in B. Rates of hyperploidy matched rates of hypoploidy in Fzr1^−/− eggs (n.s., p = 0.41; χ²). (D) Nondisjunction prevailed over PSSC in aneuploid Fzr1^−/− eggs (*p = 0.02; χ²). Parentheses in B and D indicate numbers of eggs analyzed. Scale bar in A, 2 μm.