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. 2012 Oct 11;7(10):e47226. doi: 10.1371/journal.pone.0047226

Figure 2. Brevican abundance and proteolytic processing in ADAMTS1 null and wildtype frontal cortex extracts.

Figure 2

(A) Representative immunoblots from female (F) and male (M) P8 and P28 ADAMTS1 null (−/−) and wildtype (+/+) frontal cortex protein extracts which show brevican (>145 kD, 145 kD, and 55 kD), the 55 kD ADAMTS-derived brevican fragment (EAMESE), the 53 kD MMP-derived brevican fragment (SAHPSA), and GAPDH from the corresponding immunoblots. (B) Representative immunoblots from P90 ADAMTS1 null and wildtype frontal cortex protein extracts with the same bands as in (A). (C) Representative immunoblots for P90 ADAMTS1 null and wildtype frontal cortex protein extracts which show intact versican V2 (245 kD), the ADAMTS-derived 60 kD versican fragment (NIVNSE), the MMP-derived 43 kD versican fragment (PLPDSR), and GAPDH from the corresponding immunoblots.