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Effect of coperfusion of TGR5 agonists on l-Glu/IMP-induced duodenal HCO3− secretion. Luminal coperfusion of BTA (A) or CCDC (B) with l-Glu (10 mM)/IMP (0.1 mM) further enhanced l-Glu/IMP-induced HCO3− secretion. Each data point represents mean ± SE (n = 6 rats). *P < 0.05 vs. pH 7.0 Krebs group, †P < 0.05 vs. l-Glu + IMP group.
