Fig. 9.

Effect of glucose on maximal NBD-stearic acid uptake into hepatocytes and hepatocyte nuclei. Primary mouse hepatocytes were isolated from WT, L-FABP null, SCP-2/SCP-x null, and SCP-2/SCP-x/L-FABP null mice and incubated with 0 (control) or 20 mM glucose and 0.01 μM NBD-stearic acid. Maximal NBD-stearic acid uptake into hepatocytes (A–D) and nuclei (E–H) was determined as maximal fluorescence intensity from a 0- to 60-min time curve. Values are means ± SE; n = 10–15 cells. *P < 0.05 vs. WT with the same treatment. $P < 0.05 vs. control with the same genotype.