Fig. 5.
Pregnancy-related changes in adipose tissue metabolic pathways. mRNA levels of adipose-specific enzymes and transcription factors selected from Table 2 were measured by quantitative RT-PCR analysis. Real-time CT values were normalized to actin and expressed in fold change vs. pregravid. B: diagram of the molecular pathways identified with gene ontology analysis of differentially regulated genes in early pregnancy. Statistical significance: *P < 0.05. Open bars, pregravid; filled bars, early pregnancy for n = 6 independent determinations. ELOVL6, elongation of very long chain fatty acids protein 6; ACS, acyl-CoA synthetase; FASN, fatty acid synthase; DGAT, diacylglycerol acyltransferase; ACACA, acetyl-CoA carboxylase-1α; SCD, stearoyl-CoA desaturase; GPAT, glycerol phosphate acyltransferase; LPGAT, lisophosphatidylglycerol acyltransferase; ACoA, acetyl-CoA; FADS, fatty acid desaturase; LPL, lipoprotein lipase; FOXO, forkhead box O; SREBP, sterol regulatory element-binding protein; C/EBP, CCAAT/enhancer-binding protein; PPARγ, peroxisome proliferator-activated receptor-γ.