Table 1.

Metabolic characteristics of fed and fasted rats

	Nutrient Excess			48-h Fasting
	Control	High-fat diet	Western diet	Control	High-fat diet	Western diet
Body weight, g	371.83 ± 11.37	373.33 ± 19.10	384.67 ± 13.11	379.67 ± 11.06	381.5 ± 16.1	383.0 ± 12.39
Glucose, mg/dl	234.5 ± 13.48	261.75 ± 12.28	272.33 ± 19.87†	169.33 ± 18.13‡	134.0 ± 22.91‡	163.17 ± 16.04‡
Serum insulin, ng/ml	6.51 ± 1.51	7.0 ± 3.15	9.64 ± 1.95*	0.93 ± 0.48‡	0.48 ± 0.19‡	0.43 ± 0.08‡
Cholesterol, mg/dl	89.0 ± 16.60	83.17 ± 9.00	102.17 ± 7.39*	60.33 ± 10.44‡	38.83 ± 14.72‡	49.33 ± 6.41‡
Triglyceride, mg/dl	139.75 ± 42.24	119.75 ± 12.66	379.17 ± 116.73†	50.67 ± 13.79‡	40.5 ± 19.87‡	44.67 ± 9.54‡
Free fatty acid, mEq/l	0.22 ± 0.01	0.46 ± 0.16*	0.52 ± 0.11†	0.46 ± 0.13‡	0.44 ± 0.08	0.45 ± 0.12

Results are expressed as means ± SD; n = 6. Metabolic impact of short-term fasting and nutrient excess in rats. Male Sprague-Dawley rats were subjected to 48-h fasting or 7-day high-fat diet or Western diet feeding. Body weight, fasting blood glucose level, insulin level, cholesterol, trigyceride, and serum free fatty acid level were measured.

^*P < 0.05;

^†P < 0.01 compared with control group under nutrient excess condition;

^‡P < 0.05, each group under 48-h fasting compared with its corresponding nutrient excess group.