Fig. 4.

Effect of absent caveolin-1 on intracellular Ca²⁺ ([Ca²⁺]_i) and force regulatory proteins in ASM. Compared with CTL WT, expression of the Ca²⁺ influx channel Orai1 and the M3 muscarinic receptor (AChM3R) messages were both substantially elevated by OVA (measured by quantitative RT-PCR). Absence of caveolin-1 resulted in expression of these proteins that was not substantially different from WT CTL, potentially reflecting noncaveolar expression. There was no significant difference between CTL and OVA Cav1 KO groups in this regard. Values are means ± SE (n = 4 animals). *Significant difference between CTL and OVA (P < 0.05).