Fig. 9.

Expression of inflammatory markers. mRNA levels for TNFR1 and IL4Rα were significantly increased in WT OVA, Cav1 KO CTL and OVA ASM (A) and airway epithelium (B) compared with WT CTL (measured by quantitative RT-PCR). This effect was most pronounced in Cav1 KO OVA group. The same pattern of effect was seen in the protein expression of these receptors (C). Separately, bronchoalveolar lavage (BAL) analysis showed significant increase in total cell count for WT OVA, Cav1 KO CTL, and OVA mice (D), with Cav1 KO OVA mice showing the maximal effect. Eosinophil count was also significantly increased in these 3 groups (n = 4 animals). Values are means ± SE (n = 4 animals). *Significant difference between WT and Cav1 KO; #significant difference between CTL and OVA (P < 0.05).