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A selection of ECM and non-ECM MMP-9 substrates (1, 50, 52, 115, 129, 156)
| Substrate | Effect of Cleavage on Activity |
|---|---|
| α2-Macroglobulin | ↓ |
| Plasminogen → angiostatin | ↑ |
| Endothelin-1 | ↑ |
| Fibroblast growth factor receptor 1 | Shedding |
| Growth-related oncogene-α | ↓ |
| Intercellular adhesion molecule 1 | ↓ |
| Interleukin-1β | ↑ |
| Interleukin-8 | ↑ |
| Pro-MMP-2, -9, -13 | ↑ |
| Osteopontin | ↑ |
| Platelet factor 4 | ↓ |
