Fig. 4.

Effect of β-aminopropionitrile (β-APN) on abdominal aortic aneurysms (AAA) incidence and atherosclerotic lesion area in ApoE^−/− mice on a high-fat diet with ANG II infusion. A: representative examples of ApoE^−/− mice treated with the lysyl oxidase inhibitor β-APN + ANG II. B: incidence of AAA in all groups. C: percent lesion area per total en face aortic area. *P < 0.001. D: total LOX/LOXL activity in aortic tissues of ApoE^−/− mice after 7 days of treatment. Total LOX/LOXL activity showed a trend toward decreased LOX/LOXL activity (P = 0.0576) after treatment with a high-fat diet and ANG II. RLU, relative light units, detected as a readout for H₂O₂ produced. All data are normalized to 500 μg of total protein and normalized to the β-APN inhibitable signal. LF, low fat; HF, high fat.