Table 2.
Muscle Po2mv at rest and following the onset of contractions before (control) and after selective nNOS inhibition with SMTC
| Control | SMTC | |
|---|---|---|
| Po2mv(BL), mmHg | 37.7 ± 1.2 | 44.2 ± 2.1* |
| Δ1Po2mv, mmHg | 12.4 ± 0.9 | 17.6 ± 2.1* |
| Δ2Po2mv, mmHg | 2.3 ± 0.2 | 2.6 ± 0.5 |
| ΔTotalPo2mv, mmHg | 11.0 ± 0.7 | 17.2 ± 2.1* |
| Po2mv(SS), mmHg | 26.9 ± 1.3 | 27.3 ± 2.4 |
| TD1, s | 10.1 ± 1.5 | 6.3 ± 0.7* |
| TD2, s | 73.1 ± 11.7 | 52.8 ± 14.5 |
| τ1, s | 9.6 ± 0.9 | 13.7 ± 1.8 |
| τ2, s | 59.5 ± 15.1 | 55.7 ± 4.7 |
| MRT, s | 19.7 ± 1.5 | 20.0 ± 2.0 |
| T63, s | 20.9 ± 1.9 | 19.6 ± 1.4 |
| Δ1Po2mv/τ1, mmHg/s | 1.3 ± 0.1 | 1.4 ± 0.2 |
| Po2Area, mmHg·s | 4,920 ± 244 | 5,195 ± 402 |
Values are means ± SE.
Po2mv, microvascular oxygenation; Po2mv(BL), precontracting Po2mv; Δ1Po2mv, amplitude of the first component; Δ2Po2mv, amplitude of the second component; ΔTotalPo2mv, overall amplitude regardless of one- or two-component model fit; Po2mv(SS), contracting steady-state Po2mv; TD1, time delay for the first component; TD2, time delay for the second component; τ1, time constant for the first component; τ2, time constant for the second component; MRT, mean response time; T63, time to reach 63% of the overall amplitude as determined independent of modeling procedures; Δ1Po2mv/τ1, relative rate of Po2mv fall; Po2Area, area under the Po2mv curve over the 3-min contraction period.
The two-component exponential model was used to analyze the Po2mv kinetics in the majority of instances (7 out of 11) in the control condition, whereas the one-component model was required to fit the SMTC response in most rats (9 out of 11).
P < 0.05 vs. control.