Table 1.
Baseline characteristics and biochemistry
| Parameter | Healthy Control Group (n = 21) | Normofiltration Group (n = 19) | Hyperfiltration Group (n = 18) |
|---|---|---|---|
| Baseline demographic parameters | |||
| Males | 12/20 (60%) | 11/19 (58%) | 11/18 (61%) |
| Age, yr | 24 ± 4 | 23 ± 5 | 22 ± 4 |
| Diabetes duration, yr | N/A | 18 ± 7 | 17 ± 6 |
| Weight, kg | 71 ± 8 | 72 ± 12 | 73 ± 11 |
| Height, cm | 173 ± 9 | 173 ± 9 | 172 ± 9 |
| Body mass index, kg/m2 | 24 ± 1 | 24 ± 1 | 25 ± 1 |
| Baseline biochemistry | |||
| HbA1C-%, mmol/mol | N/A | 8.8 ± 0.4 (73 ± 4) | 8.8 ± 0.5 (72 ± 5) |
| Estrogen, pmol/l (in women) | 198 ± 130 | 220 ± 40 | 204 ± 135 |
| Sodium excretion, mmol/24 h | 168 ± 20 | 173 ± 20 | 180 ± 32 |
| Protein intake, g·kg−1·day−1 | 0.92 ± 0.26 | 0.90 ± 0.31 | 0.91 ± 0.24 |
| Baseline circulating RAS mediators | |||
| Aldosterone, ng/dl | 11.6 ± 9.5 | 1.73 ± 0.68* | 1.05 ± 0.43† |
| ANG II, pg/ml | 10.2 ± 6.9 | 3.1 ± 2.2* | 2.5 ± 1.5† |
| Renin, pg/ml | 10.3 ± 5.6 | 7.6 ± 5.3 | 5.5 ± 2.0† |
| Plasma renin activity, ng·ml−1·h−1 | 1.83 ± 1.0 | 1.05 ± 0.67 | 0.71 ± 0.36† |
| Angiotensinogen, ng/ml | 1,195 ± 94 | 1,290 ± 184 | 1,593 ± 366 |
Values are means ± SD; n, number of participants.
*
P < 0.05 in normofiltering subjects vs. healthy controls;
†
P < 0.05 in hyperfiltering subjects vs. healthy controls.