Table 1.

Cardiovascular variables determined by blood pressure telemetry in Cre− control, SmCre/A1ARff, and NestinCre/A1ARff mice on diets with normal or high salt contents

	Cre−		Cre+
	NS	HS	NS	HS
SmCre/A1ARff	n = 4	n = 4	n = 7	n = 7
SAP, mmHg	115.2 ± 2.8	121.5 ± 4.1*	117.7 ± 1.5	126.4 ± 5*
MAP, mmHg	105.2 ± 2.1	113.2 ± 7.2*	104 ± 1.31	111.5 ± 1.4*
DAP, mmHg	94.6 ± 3.4	105.1 ± 4.7	89.8 ± 1.4	96.7 ± 1.1* †
PP, mmHg	20.7 ± 4.6	16.3 ± 4.8	27.8 ± 0.93	29.7 ± 1.4†
HR, beats/min	466 ± 8	461 ± 16	411 ± 6.7	462 ± 13
Activity, counts/min	5.7 ± 0.9	4.6 ± 0.9	5.4 ± 1	4.8 ± 0.9
NestinCre/A1ARff	n = 4	n = 4	n = 4	n = 4
SAP, mmHg	118.5 ± 1.4	124.6 ± 5.2	119.1 ± 1.5	125.9 ± 2.7*
MAP, mmHg	104.5 ± 1.8	109.9 ± 3.6	104.6 ± 1.1	108.8 ± 2.7
DAP, mmHg	90.4 ± 2.7	95.2 ± 3.3	89 ± 2.5	90.7 ± 4.9
PP, mmHg	29.8 ± 2.5	29.4 ± 4.8	30.1 ± 3.6	35.1 ± 6.1
HR, beats/min	494 ± 15.7	502 ± 12.6	573 ± 30.2‡	570 ± 31‡
Activity, counts/min	4.7 ± 1	3.8 ± 0.9	4.5 ± 1	2.1 ± 1

Values are means ± SE. Cre−, cre-negative control; Cre+, cre-positive mice; NS, normal salt diet; HS, high salt diet; SAP, systolic arterial pressure; MAP, mean arterial pressure; DAP, diastolic arterial pressure; PP, pulse pressure; HR, heart rate.

^*Significant difference between HS and NS (P < 0.05). Significant difference between genotypes for a given diet:

^†P < 0.05;

^‡P < 0.1.