Skip to main content
. 2012 Jul 18;303(7):F1026–F1036. doi: 10.1152/ajprenal.00410.2011

Fig. 7.

Fig. 7.

Decreased subpodocyte space (SPS) coverage accompanies increased glomerular water permeability of VEGF164 overexpressing mice. A and B: High-power electron micrographs of the glomerular capillary wall from control mice (A), double-transgenic pod/tet-VEGF164 mice (B), and triple-transgenic pod/tet-VEGF164/neph-VEGF165b mice (C) treated with doxycycline-supplemented drinking water for 7 days to induce conditional overexpression of murine VEGF164 in podocytes. L, capillary lumen; pod: podocyte; arrow: podocyte foot process in SPS-free region; par: parietal epithelial cell lining Bowman's capsule. *SPS. Scale bars: 1 μm. D: significant reduction in SPS coverage of the glomerular capillary wall in VEGF164-overexpressing mice (black bar), compared with littermate control mice (open bar) and VEGF164/VEGF165b co-overexpressing mice (*P < 0.05, one-way ANOVA). E: distance between fenestrae tended to reduce (P = 0.1, one-way ANOVA) in VEGF164-overexpressing mice but was significantly increased in VEGF164/VEGF165b co-overexpressing mice (*P < 0.05, one-way ANOVA). There were no significant differences between groups in glomerular basement membrane width (F) or in podocyte foot width (G). Numbers in columns represent number of glomerular capillaries examined in each group.