Table 3.
Summary of significant main-effect QTL linked to albuminuria
| Chr | QTL Name | Population | Peak, cM | 95% CI, cM | 95% CI, Mb | LOD | High Allele | ACR Effect* | Mode of Inheritance | Human QTL |
|---|---|---|---|---|---|---|---|---|---|---|
| 4 | Albq12 | SJL × RIIIS | 26.1 | 16.1–32.1 | 34.0–58.4 | 7.61 | RIIIS | 16.5 | Rec | 9q22 (32) |
| 6 | Albq13 | BTBR × SWR | 6.8 | 2.8–12.8 | 6.8–32.0 | 3.82 | SWR | 34.3 | Rec | 7q21 (24) |
| 7 | Albq14 | PL × CBA | 64.4 | 34.4–74.4 | 70.0–138.7 | 3.32 | PL | 48.3 | Rec | 16p12 (4) |
| 13 | Albq15 | C3H × KK | 36.7 | 14.7–44.7 | 37.4–84.8 | 3.86 | KK | 44.2 | Add | 9q22 (32), 5q14 (28) |
| 17 | Albq16 | 129 × A | 5.5 | 0–11.5 | 0–23.3 | 7.71 | A | 78.8 | Rec | 6p21 (32), 6q26 (7) |
| 18 | Albq17 | 129 × D2 | 9.7 | 0–17.7 | 0–30.9 | 4.51 | D2 | 20.2 | Rec | 18q12 (32) |
| 10 | Albq18 | preCC | 4.7 | 3.0–5.1 | 8.7–13.5 | 9.0 | WSB | n/a | n/a |
CI, confidence interval; cM, centimorgan; Mb, megabase; LOD, logarithm of the odds ratio; Rec, recessive; Add, additive; n/a, not availalbe.
Reference for each human QTL is indicated in parentheses.
*
ACR effect is the maximum ACR difference between the three genotypes at the QTL expressed as mg albumin/g creatinine.