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Line graph shows changes in renal perfusion pressure in response to RSNS in homozygous A1 receptor knockout (A1AR−/−), littermate heterozygous (A1AR−/+), and littermate wild-type (A1AR+/+) kidneys. P values in panels are from nested 2-factor ANOVA comparing the 3 different genotypes; aP < 0.05 compared with corresponding value in the A1AR+/+ group (Fisher's LSD test). All values represent means ± SE.
