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. 2012 Aug 23;303(8):G951–G960. doi: 10.1152/ajpgi.00158.2012

Fig. 4.

Fig. 4.

MLK signaling is required for activation of ERK and JNK signaling in vitro in confluent Caco-2 cells. A: MLK inhibitor CEP-11004 reduces ERK phosphorylation in confluent Caco-2 cells (n = 6) after 24 h. B and C: CEP-11004 reduces JNK phosphorylation (n = 6) and increases total PTEN levels (n = 6) in Caco-2 cells. D and E: CEP-11004 does not affect p38 signaling (n = 6) or phosphorylated AKT levels (n = 6). F: levels of cleaved caspase-3 are not changed after 24 h of treatment with CEP-11004. *P < 0.05.