Table 1.
Morphometric parameters of WT and MLK3 KO mouse intact small intestine and proliferation rate in the mucosa at the ulcer edge and intact area of experimental animals
| Ki-67-Positive Cells, % |
Thickness, μm |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Intact area | Ulcer edge at 5 days | Mucosa | Stroma | Total | Crypt Depth, μm | Villous Height, μm | Cells per 100 μm of Villi | Villus Width, μm | Villus Cell Area, μm2 | |
| WT | 76.4 ± 1.9 | 73.6 ± 2.1 | 441.7 ± 24.7 | 63.5 ± 3.8 | 492.5 ± 26.4 | 137.3 ± 12.5 | 330 ± 20.2 | 16.2 ± 5.5 | 83.1 ± 3.5 | 12.5 ± 1.3 |
| MLK3 KO | 74.8 ± 1.5 | 75.0 ± 1.4 | 602.3 ± 17.1* | 97.7 ± 6.0* | 690.2 ± 22.8* | 171 ± 8.3* | 405 ± 13.8* | 20.2 ± 7.5* | 113.5 ± 8.9* | 10.2 ± 0.5 |
Values are means ± SE; n = 6–12.
MLK3, mixed-lineage kinase 3; WT, wild-type; KO, knockout.
*
P < 0.05.