Table 3.
Summary of results from multivariate analyses assessing the relationship between risk of incident diabetes and serum potassium levels.
Adjusted Relative Hazards (RH) for Incident Diabetes# | ||||
---|---|---|---|---|
Model (n total; cases of incident diabetes) | K < 4.0 | 4.0 ≤ K < 4.5 | 4.5 ≤ K < 5.0 | K 5.0-5.5 (ref)% |
Main model (n=12,209; 1475) | 1.64 (1.29-2.08) | 1.64 (1.34-2.01) | 1.39 (1.14-1.71) | 1.00 |
Subjects not on medications* (n=9,353; 930) | 1.57 (1.14-2.16) | 1.48 (1.17-1.88) | 1.38 (1.09-1.74) | 1.00 |
Subjects not on diuretics (n=10,373; 1118) | 1.41 (1.06-1.88) | 1.51 (1.21-1.87) | 1.35 (1.09-1.67) | 1.00 |
Subjects on diuretics (n=1835; 357) | 2.91 (1.41-6.00) | 2.85 (1.38-5.88) | 1.93 (0.92-4.08) | 1.00 |
Subject self-report of diabetes, 9 years (n=12,209; 607) | 1.46 (0.99-2.16) | 1.39 (0.99-1.95) | 1.47 (1.05-2.06) | 1.00 |
Subject self-report of diabetes, 17 years (n=12,209; 2552) | 1.24 (1.04-1.48) | 1.29 (1.11-1.49) | 1.31 (1.13-1.51) | 1.00 |
RH and OR adjusted for for age, sex, race, center, BMI, waist circumference, serum magnesium, calcium, and creatinine levels, physical activity, parental history of diabetes, presence of hypertension, systolic blood pressure, fasting glucose and insulin, income, use of beta-blockers, use of diuretics (unless indicated otherwise), and use of ACE-Is
subjects not on beta-blockers, ACE-inhibitors, diuretics, potassium or magnesium supplementation
% K= serum potassium in mEq/L