Delayed peak proliferation in the hepFXR-KO mice after PHX. Representative photomicrographs of PCNA immunohistochemical staining of liver sections from Control (A, C, E, and G) and hepFXR-KO (B, D, F, and H) mice at 1, 2, 3 and 7 days after PHX. Arrowheads point to cells in S-phase.