Skip to main content
. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Hepatology. 2012 Dec;56(6):2344–2352. doi: 10.1002/hep.25918

Figure 3.

Figure 3

Delayed Cyclin D1 expression and phosphorylation of Rb in hepFXR-KO mice after PHX. (A) Real Time PCR analysis of Cyclin D1 mRNA in the liver of Control and hepFXR-KO mice after PHX. *P<0.5 (B) Western blot analysis of Cyclin D1, CDK4 and pRb using RIPA extract of Control and hepFXR-KO livers obtained at various time points after PHX. (C) Co-IP analysis of CDK4-Cyclin D1 complex formation at 1 day after PHX in Control and hepFXR-KO mice. (D) Densitometric analysis of the co-IP blots (E) Western blot analysis of cell cycle inhibitors p21 and p27 using RIPA extract of Control and hepFXR-KO livers obtained at various time points after PHX.