Table 2. Fitted Results for Two-pool Models Under Various Conditions.

Both of the two-pool models were fit to the HP lactate curve with and without the pyruvate HP data. The first set was done without pyruvate; secondly, the initial value of the pyruvate decay was included as a normalization factor. The third set was done with the pyruvate time-course included as well as the initial value and then the last set was done by excluding the decay due to pulsing. All of these models fit the lactate curve well. Flux is the initial flux from pyruvate into lactate at time t = 0 in μmol/billion cells/hr.

	Two-pool Bidirectional (P ↔ L)				Two-pool Unidirectional (P → L)
	flux	T1L (s)	pw	T1P (s)	flux	T1L (s)	pw	T1P (s)
HP Lactate Fit
No Pyruvate	989	43	9.0°	57	6356	54	3.4°	51
Lactate & Pyr (t=0)	242	45	9.3°	59	236	32	16.8°	60
HP Lactate and Pyruvate Fit
With RF signal decay	223	294	1.2°	46	217	37	10.4°	48
Ignore decay	223	179	-	47	219	25	-	48
Large decay (18°)	216	224	-	48	214	64	-	48