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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Mol Cancer Ther. 2012 Aug 28;11(10):2243–2253. doi: 10.1158/1535-7163.MCT-12-0135

Figure 1. MI-63- and Nutlin-resistant cells show cross-resistance to HDM-2 inhibitors.

Figure 1

(A) Chemical structure MI-63. (B) Chemical structure RITA. Granta-519 (C, E, G) and H929 (D, F, H) wild type (WT) cells, along with their MI-63-resistant (MI63R) and Nutlin-resistant (NutlinR) counterparts, were treated for 72-hours with MI-63, Nutlin or RITA. Cell viability was determined using the WST-1 reagent, and results were expressed as the percentage viability relative to vehicle controls, which were arbitrarily set at 100%. IC50 values for MI-63, Nutlin and RITA-exposed conditions were determined, and fold changes in the IC50 were calculated relative to WT cells (Supplementary Table 1).