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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Mol Cancer Ther. 2012 Aug 28;11(10):2243–2253. doi: 10.1158/1535-7163.MCT-12-0135

Figure 5. Simultaneous addition of RITA with MI-63 is synergistic in MI-63-resistant cell lines.

Figure 5

Granta.MI63R (A) and H929.63R (B) cells were incubated with MI-63 or RITA for 24- and 48-hours. In parallel, Granta.MI63R (C) and H929.63R (D) cells were exposed to MI-63 and RITA simultaneously, or first to MI-63 for 24-hours followed by RITA and MI-63 for 48-hours, or to RITA first for 24-hours followed later by MI-63 and RITA for 48-hours. Cell viability was determined using the WST-1 reagent, and results were expressed relative to the vehicle control. An unpaired T test was performed on conditions in panels C and D, where * designates p<0.05 relative to the vehicle control, and # designates p<0.05 relative to the simultaneous addition of RITA and MI-63.