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. Author manuscript; available in PMC: 2012 Nov 11.
Published in final edited form as: J Med Chem. 2012 Oct 1;55(19):8549–8558. doi: 10.1021/jm301189c

Figure 1.

Figure 1

Design of a new type of PDE9 inhibitors. (A) Surface presentation of 10r binding to the pocket of PDE9A2. Color codes are white for carbon, blue for nitrogen, red for oxygen of PDE9A2, and orange for chlorine. Inhibitor 10r is shown in both surface and stick models (light green). (B) Design of a scaffold that may potentially form a hydrogen bond with Tyr424 and fit tightly to the PDE9 pocket.