. Author manuscript; available in PMC: 2013 Oct 11.

Published in final edited form as: J Med Chem. 2012 Sep 20;55(19):8392–8408. doi: 10.1021/jm300780p

Table 2.

In vitro hTRPV1 Antagonistic Activities for 2-Pyrrolidinyl Derivatives

	K_i [CAP] (nM)	IC₅₀ [pH] (nM)		K_i [CAP] (nM)	IC₅₀ [pH] (nM)
33	0.6	211	39^*	1.4	50
34^*	0.3	WE	40^*	101	WE
35^*	WE	NE	41^*	103	WE
36^*	WE	NE	42^*	11	757
37^*	2.6	209	43^*	7.1	737
38^*	WE	WE	44	5	192

(S)-propanamide